A patient experiencing hyporeflexia has symptoms consistent with neuropathy. Which medication is often associated with similar symptoms?

Vincristine is frequently associated with peripheral neuropathy, which can manifest as hyporeflexia and other symptoms like numbness, tingling, and weakness. This is due to its mechanism of action which disrupts microtubule function, ultimately affecting axonal transport in neurons and leading to neuropathic symptoms. The neurotoxic effects of vincristine are well-documented, and its use in treatment regimens for certain cancers raises the likelihood of patients experiencing these specific neurological deficits.

While other chemotherapeutic agents can also lead to neuropathy, the characteristic peripheral neuropathy seen with vincristine sets it apart. In contrast, agents like cisplatin, doxorubicin, and paclitaxel have different primary toxicities and mechanisms that lead to other types of side effects, making vincristine the most closely related to the symptoms described in this scenario.