What condition is characterized by delayed immune responses and is most likely associated with a recent Group A Streptococcus infection?

Prepare for the NBME Form 26 Test. Study with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Rheumatic fever is characterized by delayed immune responses that occur following an infection with Group A Streptococcus, commonly known for causing strep throat. This condition arises when the body's immune system reacts disproportionately to the streptococcal bacteria, leading to inflammatory responses that can cause damage to the heart, joints, skin, and nervous system.

In rheumatic fever, the immune response can be delayed, often manifesting several weeks after the initial infection. This delay is due to the development of antibodies against the streptococcal bacteria, which may cross-react with the body’s own tissues, particularly in the heart, leading to rheumatic heart disease and other complications.

The association of rheumatic fever with a recent streptococcal infection sets it apart from the other conditions listed. Unlike rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes, which do not have a direct link to Group A Streptococcus, rheumatic fever is specifically triggered by preceding strep infections, making it a unique and important condition to recognize in the context of delayed immune responses.

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